Amikacin or Vancomycin Exposure Alters the Postnatal Serum Creatinine Dynamics in Extreme Low Birth Weight Neonates

نویسندگان

چکیده

Background: Disentangling renal adverse drug reactions from confounders remains a major challenge to assess causality and severity in neonates, with additional limitations related the available tools (modified Kidney Disease Improving Global Outcome, or Division of Microbiology Infectious Diseases pediatric toxicity table). Vancomycin amikacin are nephrotoxic while still often prescribed neonates. We selected these compounds their impact on creatinine dynamics as sensitive tool detect impairment signal. Methods: A recently developed dynamical model that characterized serum concentrations 217 extremely low birth weight (<1000 g, ELBW) neonates (4036 observations) was enhanced data vancomycin and/or exposure identify potential effect antibiotic by nonlinear mixed-effects modelling. Results: Seventy-seven percent ELBW patients were exposed either amikacin. Antibiotic resulted modest increase transient decrease clearance. The dependent gestational age, illustrated 56% difference between 24 32-week old neonate, when 3rd week after birth. Conclusions: previously described used explore quantify dynamics. Such serve minor changes, compare differences treatment modalities.

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ژورنال

عنوان ژورنال: International Journal of Environmental Research and Public Health

سال: 2021

ISSN: ['1661-7827', '1660-4601']

DOI: https://doi.org/10.3390/ijerph18020662